Organized at Lafayette, Ind., in December, 1861, and ordered immediately into Kentucky, where it went into a Camp of Instruction near Bardstown. In February, 1862, it moved with Buell's Army on its various campaigns in Kentucky and Tennessee, having been assigned to Wagner's Brigade of Wood's Division, in which it was present at Shiloh, but not under fire. Wood's (6th) Division participated in the campaigns of the Army of the Ohio in 1862, the occupation of Tennessee, and the retreat into Kentucky. The regiment was engaged at Stone's River, where it lost 4 killed, 68 wounded, and 13 missing. The brigade was absent at Chickamauga, it having been detailed just at that time on duty at Chattanooga, and left behind as the army passed through. Upon the re-organization of the Army of the Cumberland, October 20, 1863, the regiment was assigned to Wagner's (2d) Brigade, Sheridan's (2d) Division, Fourth Corps, in which command it fought at Missionary Ridge, where it sustained a loss of 20 killed and 138 wounded; total, 158. During the Atlanta campaign, General Newton commanded the division, and in the unsuccessful assault on Kenesaw Mountain the regiment met with another severe loss, the percentage of casualties being very large. At the battle of Franklin, General Wagner commanded the division, and Colonel John Q. Lane the brigade. After the battle at Nashville the regiment remained in winter-quarters near that city until the spring of 1865, when, the war having closed, it was ordered to New Orleans. From there it went with the Fourth Corps to Texas, where it joined Sheridan's Army of Occupation, remaining there until December 21, 1865, when it was mustered out.